Evolution of H5 subtype avian influenza A viruses in North America
Identifieur interne : 001B50 ( Main/Exploration ); précédent : 001B49; suivant : 001B51Evolution of H5 subtype avian influenza A viruses in North America
Auteurs : M. García [États-Unis] ; D. L Suarez [États-Unis] ; J. M Crawford [États-Unis] ; J. W Latimer [États-Unis] ; R. D Slemons [États-Unis] ; D. E Swayne [États-Unis] ; M. L Perdue [États-Unis]Source :
- Virus Research [ 0168-1702 ] ; 1997.
English descriptors
- Teeft :
- Allele, Amino, Amino acid distances, Amino acid positions, Amino acid sequences, Amino acid substitutions, Amino acids, Aquatic birds, Atlantic flyway, Available hosts, Avian, Avian influenza, Avian influenza virus, Avian influenza viruses, Central mexico, Clade, Cleavage site, Coding changes, Coding sequence, Commercial chicken, Commercial chickens, Commercial poultry, Common ancestor, Domestic poultry, Fusion peptide, Garcia, Gene, Gene lineage, Gene sequences, Glycosylation, Glycosylation site, Hemagglutinin, Hemagglutinin genes, Hinshaw, Human influenza, Influenza, Influenza virus, Influenza viruses, International symposium, Kawaoka, Life technologies, Lineage, Migratory waterfowl, Mutation, Mutation rate, Nucleotide, Ohio state university, Outbreak, Pathogenic, Phylogenetic, Phylogenetic analysis, Phylogenetic relationship, Phylogenetic relationships, Phylogenetic trees, Positive colonies, Poultry market chickens, Poultry markets, Poultry outbreak, Poultry research laboratory, Proteolytic cleavage site, Receptor, Receptor binding pocket, Receptor binding site, Same laboratory, Same time, Senne, Separate clades, Sequence accession number, Sequence analysis, Sequence data, Significant sequence variation, Slemons, Subtype, Subtype viruses, Subtypes, Tissue tropism, Virus, Virus research, Waterfowl, Waterfowl origin virus, Waterfowl virus, Waterfowl viruses, Wild duck populations.
Abstract
Abstract: The phylogenetic relationships of the hemagglutinin (HA) and non-structural (NS) genes from avian influenza (AI) H5 subtype viruses of North American origin are presented. Analysis of the HA genes of several previously uncharacterized isolates from waterfowl and turkeys provided clear evidence of significant sequence variation and existence of multiple virus clades or sub-lineages, maintained in migratory waterfowl. Phylogenetic analysis of NS gene sequences further demonstrated multiple sub-lineages and also demonstrated re-assortment of two NS alleles in wild duck populations. Based on currently available HA1 gene sequences, at least four clades exist with waterfowl isolates included in three of the four groups. The most genetically unstable of these sub-lineages is composed of recent poultry isolates from the outbreak of AI in Central Mexico. This group of viruses, which replicated unabated in chickens for at least 16 months, exhibited an increased rate of mutation in both the HA and NS gene. Comparison of the HA1 sequence data for all available North American H5 subtype viruses demonstrated minimal variation both in and around the amino acids predicted to be involved in the HA receptor binding site. The sequences also revealed that migratory waterfowl, live poultry market chicken, and turkey isolates uniformly lack a glycosylation site at amino acid 236 in the HA protein which is present in commercial chicken isolates.
Url:
DOI: 10.1016/S0168-1702(97)00087-7
Affiliations:
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D Slemons</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Swayne, D E" sort="Swayne, D E" uniqKey="Swayne D" first="D. E" last="Swayne">D. E Swayne</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>USDA, Agriculture Research Service, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30605</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Perdue, M L" sort="Perdue, M L" uniqKey="Perdue M" first="M. L" last="Perdue">M. L Perdue</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>USDA, Agriculture Research Service, Southeast Poultry Research Laboratory, 934 College Station Road, Athens, GA 30605</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Virus Research</title><title level="j" type="abbrev">VIRUS</title><idno type="ISSN">0168-1702</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="115">115</biblScope><biblScope unit="page" to="124">124</biblScope></imprint><idno type="ISSN">0168-1702</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0168-1702</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Amino</term><term>Amino acid distances</term><term>Amino acid positions</term><term>Amino acid sequences</term><term>Amino acid substitutions</term><term>Amino acids</term><term>Aquatic birds</term><term>Atlantic flyway</term><term>Available hosts</term><term>Avian</term><term>Avian influenza</term><term>Avian influenza virus</term><term>Avian influenza viruses</term><term>Central mexico</term><term>Clade</term><term>Cleavage site</term><term>Coding changes</term><term>Coding sequence</term><term>Commercial chicken</term><term>Commercial chickens</term><term>Commercial poultry</term><term>Common ancestor</term><term>Domestic poultry</term><term>Fusion peptide</term><term>Garcia</term><term>Gene</term><term>Gene lineage</term><term>Gene sequences</term><term>Glycosylation</term><term>Glycosylation site</term><term>Hemagglutinin</term><term>Hemagglutinin genes</term><term>Hinshaw</term><term>Human influenza</term><term>Influenza</term><term>Influenza virus</term><term>Influenza viruses</term><term>International symposium</term><term>Kawaoka</term><term>Life technologies</term><term>Lineage</term><term>Migratory waterfowl</term><term>Mutation</term><term>Mutation rate</term><term>Nucleotide</term><term>Ohio state university</term><term>Outbreak</term><term>Pathogenic</term><term>Phylogenetic</term><term>Phylogenetic analysis</term><term>Phylogenetic relationship</term><term>Phylogenetic relationships</term><term>Phylogenetic trees</term><term>Positive colonies</term><term>Poultry market chickens</term><term>Poultry markets</term><term>Poultry outbreak</term><term>Poultry research laboratory</term><term>Proteolytic cleavage site</term><term>Receptor</term><term>Receptor binding pocket</term><term>Receptor binding site</term><term>Same laboratory</term><term>Same time</term><term>Senne</term><term>Separate clades</term><term>Sequence accession number</term><term>Sequence analysis</term><term>Sequence data</term><term>Significant sequence variation</term><term>Slemons</term><term>Subtype</term><term>Subtype viruses</term><term>Subtypes</term><term>Tissue tropism</term><term>Virus</term><term>Virus research</term><term>Waterfowl</term><term>Waterfowl origin virus</term><term>Waterfowl virus</term><term>Waterfowl viruses</term><term>Wild duck populations</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The phylogenetic relationships of the hemagglutinin (HA) and non-structural (NS) genes from avian influenza (AI) H5 subtype viruses of North American origin are presented. Analysis of the HA genes of several previously uncharacterized isolates from waterfowl and turkeys provided clear evidence of significant sequence variation and existence of multiple virus clades or sub-lineages, maintained in migratory waterfowl. Phylogenetic analysis of NS gene sequences further demonstrated multiple sub-lineages and also demonstrated re-assortment of two NS alleles in wild duck populations. Based on currently available HA1 gene sequences, at least four clades exist with waterfowl isolates included in three of the four groups. The most genetically unstable of these sub-lineages is composed of recent poultry isolates from the outbreak of AI in Central Mexico. This group of viruses, which replicated unabated in chickens for at least 16 months, exhibited an increased rate of mutation in both the HA and NS gene. Comparison of the HA1 sequence data for all available North American H5 subtype viruses demonstrated minimal variation both in and around the amino acids predicted to be involved in the HA receptor binding site. The sequences also revealed that migratory waterfowl, live poultry market chicken, and turkey isolates uniformly lack a glycosylation site at amino acid 236 in the HA protein which is present in commercial chicken isolates.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Ohio</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Garcia, M" sort="Garcia, M" uniqKey="Garcia M" first="M" last="García">M. García</name></region><name sortKey="Crawford, J M" sort="Crawford, J M" uniqKey="Crawford J" first="J. M" last="Crawford">J. M Crawford</name><name sortKey="Latimer, J W" sort="Latimer, J W" uniqKey="Latimer J" first="J. W" last="Latimer">J. W Latimer</name><name sortKey="Perdue, M L" sort="Perdue, M L" uniqKey="Perdue M" first="M. L" last="Perdue">M. L Perdue</name><name sortKey="Slemons, R D" sort="Slemons, R D" uniqKey="Slemons R" first="R. D" last="Slemons">R. D Slemons</name><name sortKey="Suarez, D L" sort="Suarez, D L" uniqKey="Suarez D" first="D. L" last="Suarez">D. L Suarez</name><name sortKey="Swayne, D E" sort="Swayne, D E" uniqKey="Swayne D" first="D. E" last="Swayne">D. E Swayne</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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